<p>指南者留学全国统一咨询热线：<a href="tel:4001831832" style="color:#1677ff; text-decoration:none;">400-183-1832</a>，全国各地区、各分公司联系方式均为此号码。</p><section style="font-size: 16px;" data-role="outer"> <section style="font-family: Optima-Regular, PingFangTC-light; line-height: 1.75; padding: 0px 15px; box-sizing: border-box; text-align: justify; font-size: 16px;"> <section style="text-align: center; margin-top: 10px; margin-bottom: 10px; line-height: 0; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; width: 510px; height: 340px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/168266349439244.jpeg" width="510" height="340" data-ratio="0.6666666666666666" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/168266349439244.jpeg" data-w="1080" /></section> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 0px 0px -20px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="text-align: justify; padding: 0px 15px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 12px; color: #54504f; box-sizing: border-box;">浸大中医药学院教学科研部助理教授<strong style="box-sizing: border-box;">王凯亮博士</strong>（左）及研究人员<strong style="box-sizing: border-box;">郭轩铭博士</strong>（右）介绍有关新冠病毒进入细胞的机制及治疗标靶的研究成果。</span></p> </section> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 10px 0px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: auto; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: #1a3b91; min-width: 5%; max-width: 100%; height: auto; padding: 0px 16px; box-sizing: border-box;"> <section style="margin: 0px; box-sizing: border-box;"> <section style="color: #ffffff; font-size: 21px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;">News</strong></p> </section> </section> </section> </section> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; vertical-align: top; width: 33.33%; box-sizing: border-box;"> <section style="margin: 11px 0px 8px; box-sizing: border-box;"> <section style="background-color: rgba(62, 62, 62, 0.66); height: 1px; box-sizing: border-box;"></section> </section> </section> <section style="display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; max-width: 100%; height: auto; padding: 0px 14px; box-sizing: border-box;"> <section style="text-align: justify; font-size: 12px; color: rgba(62, 62, 62, 0.66); box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">SARS-CoV-2 &amp; COVID-19</p> </section> <section style="box-sizing: border-box; transform: rotateZ(45deg);"> <section style="margin: 6px 0px 0px; box-sizing: border-box; transform: translate3d(-6px, 0px, 0px);"> <section style="display: inline-block; width: 15px; height: 15px; vertical-align: top; overflow: hidden; border-style: solid; border-width: 0px 3px 3px 0px; border-color: #c30503 #1a3b91 #1a3b91 #c30503; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> </section> <section style="display: inline-block; vertical-align: top; width: 33.33%; box-sizing: border-box;"> <section style="margin: 11px 0px 8px; box-sizing: border-box;"> <section style="background-color: rgba(62, 62, 62, 0.66); height: 1px; box-sizing: border-box;"></section> </section> </section> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">香港浸会大学（浸大）科学家领导的研究发现一种名为MT1-MMP的蛋白酶</strong></span>，它决定了「严重急性呼吸综合症冠状病毒2」（SARS-CoV-2，以下简称新型冠状病毒）在人体内传染的能力，并且是导致新冠感染影响不同器官的主要因素。研究团队采用一种名为3A2的人源化抗体，以抑制MT1-MMP的活动，结果令受感染小鼠的病毒量减少近九成，<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">证明MT1-MMP这种蛋白酶有条件成为治疗2019冠状病毒病的标靶</strong></span>。</p> </section> <section style="transform-origin: center center; margin-top: 6px; margin-bottom: 6px; box-sizing: border-box; transform: scale(1.25);"> <section style="text-align: center; margin: 10px 0px -29px; line-height: 0; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"></section> </section> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="text-align: center; margin-top: 10px; margin-bottom: 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 560px; box-sizing: border-box; height: 292px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663494846521.jpeg" width="560" height="292" data-ratio="0.521484375" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663494846521.jpeg" data-w="1024" /></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="transform-origin: center center; margin-top: 3px; margin-bottom: 3px; box-sizing: border-box; transform: scale(1.2);"> <section style="text-align: center; margin: -28px 0px 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"></section> </section> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="text-align: left; margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 15px; box-sizing: border-box;">该项研究成果已发表于国际知名科学期刊《Nature Communications》。</span></p> </section> <section style="transform-origin: center center; margin-top: 6px; margin-bottom: 6px; box-sizing: border-box; transform: scale(1.25);"> <section style="text-align: center; margin: 10px 0px -58px; line-height: 0; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"></section> </section> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 0px; box-sizing: border-box;"> <section style="display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; max-width: 100%; height: auto; box-sizing: border-box;"> <section style="text-align: center; box-sizing: border-box;"> <section style="display: inline-block; width: 34px; height: 64px; vertical-align: top; overflow: hidden; background-color: #1a3b91; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> <section style="display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; max-width: 100%; height: auto; box-sizing: border-box;"> <section style="box-sizing: border-box; transform: translate3d(-23px, 0px, 0px);"> <section style="font-size: 19px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #f2f9ff; box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="font-size: 36px; box-sizing: border-box;">0</span></strong></span><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="font-size: 36px; box-sizing: border-box;">1</span></strong></span></p> </section> </section> </section> <section style="display: inline-block; vertical-align: middle; width: auto; min-width: 5%; max-width: 100%; flex: 0 0 auto; height: auto; align-self: center; box-sizing: border-box;"> <section style="text-align: center; box-sizing: border-box;"> <section style="display: inline-block; width: 16px; height: 31px; vertical-align: top; overflow: hidden; background-color: rgba(115, 115, 115, 0.34); box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> <section style="display: inline-block; vertical-align: top; width: 70%; flex: 0 0 auto; height: auto; box-sizing: border-box;"> <section style="box-sizing: border-box; transform: translate3d(20px, 0px, 0px);"> <section style="text-align: justify; font-size: 20px; color: #54504f; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">ACE2作为新型冠状病毒</strong></em><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">进入细胞的受体&nbsp;</strong></em></p> </section> </section> </section> </section> <section style="margin: 0.5em 0px; box-sizing: border-box;"> <section style="background-color: rgba(54, 54, 54, 0.58); height: 2px; box-sizing: border-box;"></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 15px 0px 25px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 0) 70%, rgba(26, 59, 145, 0.96) 70%, rgba(26, 59, 145, 0.96) 100%); height: auto; padding: 0px 10px 10px; box-sizing: border-box;"> <section style="display: flex; width: 100%; flex-flow: column nowrap; box-sizing: border-box;"> <section style="z-index: 1; box-sizing: border-box;"> <section style="text-align: left; margin: 10px 0px -40px; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="display: inline-block; width: auto; height: 26px; vertical-align: top; overflow: hidden; background-color: rgba(214, 207, 205, 0.63); min-width: 5%; max-width: 100%; box-sizing: border-box; border: 0px none #ffffff;"> <section style="text-align: justify; color: rgba(214, 207, 205, 0.63); box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: rgba(0, 0, 0, 0.01); box-sizing: border-box;"> &nbsp;。</span></p> </section> </section> </section> </section> </section> <section style="margin: 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 531px; box-sizing: border-box; height: 354px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495793266.jpeg" width="531" height="354" data-ratio="0.6657407407407407" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495793266.jpeg" data-w="1080" /></section> </section> </section> </section> <section style="text-align: left; box-sizing: border-box; transform: translate3d(5px, 0px, 0px);"> <section style="text-align: right; padding: 0px 20px; box-sizing: border-box;"> <p style="text-align: justify; margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 12px; color: #1a3b91; box-sizing: border-box;">►&nbsp;<span style="color: #54504f; box-sizing: border-box;">了解新型冠状病毒进入细胞的机制，对抑制病毒的传播以及寻找新的新冠治疗方案极为重要。</span></span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="transform-origin: center center; margin-top: 3px; margin-bottom: 3px; box-sizing: border-box; transform: scale(1.2);"> <section style="text-align: center; margin: -28px 0px 0px; line-height: 0; box-sizing: border-box;"></section> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">接种疫苗可为人们提供保护，免受2019冠状病毒病及其并发症的威胁，但它对免疫系统较弱的人士，或面对一些主要变种病毒时，并非经常有效。因此，开发更有效的新冠治疗方案，在后疫苗时代仍然是一个巨大挑战。<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">了解新型冠状病毒进入细胞的机制，对抑制病毒的传播以及寻找新的新冠治疗方案极为重要。</strong></span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">新型冠状病毒需要「血管紧张素转换酶2」（ACE2）作为其进入细胞的受主。ACE2是人类细胞膜上的蛋白质。虽然肺部是受新型冠状病毒感染影响的主要器官，但ACE2只表现于少部分肺部细胞。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">过去有研究发现，新型冠状病毒依赖可溶性ACE2，也能感染只有少量ACE2表现的器官。<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">可溶性ACE2与新型冠状病毒结合，将病毒携带至只有少量ACE2表现的细胞，并帮助病毒进入这些细胞。</strong></span></p> </section> <section style="transform-origin: center center; margin-top: 6px; margin-bottom: 6px; box-sizing: border-box; transform: scale(1.25);"> <section style="text-align: center; margin: 10px 0px -29px; line-height: 0; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"></section> </section> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 0px; box-sizing: border-box;"> <section style="display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; max-width: 100%; height: auto; box-sizing: border-box;"> <section style="text-align: center; box-sizing: border-box;"> <section style="display: inline-block; width: 34px; height: 64px; vertical-align: top; overflow: hidden; background-color: #1a3b91; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> <section style="display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; max-width: 100%; height: auto; box-sizing: border-box;"> <section style="box-sizing: border-box; transform: translate3d(-23px, 0px, 0px);"> <section style="font-size: 19px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="font-size: 36px; box-sizing: border-box;"><span style="color: #f2f9ff; box-sizing: border-box;">0</span><span style="color: #1a3b91; box-sizing: border-box;">2</span></span></strong></p> </section> </section> </section> <section style="display: inline-block; vertical-align: middle; width: auto; min-width: 5%; max-width: 100%; flex: 0 0 auto; height: auto; align-self: center; box-sizing: border-box;"> <section style="text-align: center; box-sizing: border-box;"> <section style="display: inline-block; width: 16px; height: 31px; vertical-align: top; overflow: hidden; background-color: rgba(115, 115, 115, 0.34); box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> <section style="display: inline-block; vertical-align: top; width: 70%; flex: 0 0 auto; height: auto; box-sizing: border-box;"> <section style="box-sizing: border-box; transform: translate3d(20px, 0px, 0px);"> <section style="font-size: 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #54504f; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">MT1-MMP调节SARS-CoV-2进入细胞</strong></em></span></p> </section> </section> </section> </section> <section style="margin: 0.5em 0px; box-sizing: border-box;"> <section style="background-color: rgba(54, 54, 54, 0.58); height: 2px; box-sizing: border-box;"></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 15px 0px 25px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 0) 70%, rgba(26, 59, 145, 0.96) 70%, rgba(26, 59, 145, 0.96) 100%); height: auto; padding: 0px 10px 10px; box-sizing: border-box;"> <section style="display: flex; width: 100%; flex-flow: column nowrap; box-sizing: border-box;"> <section style="z-index: 1; box-sizing: border-box;"> <section style="text-align: left; margin: 10px 0px -40px; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="display: inline-block; width: auto; height: 26px; vertical-align: top; overflow: hidden; background-color: rgba(214, 207, 205, 0.63); min-width: 5%; max-width: 100%; box-sizing: border-box; border: 0px none #ffffff;"> <section style="text-align: justify; color: rgba(214, 207, 205, 0.63); box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: rgba(0, 0, 0, 0.01); box-sizing: border-box;"> &nbsp;。</span></p> </section> </section> </section> </section> </section> <section style="margin: 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 502px; box-sizing: border-box; height: 335px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495653978.jpeg" width="502" height="335" data-ratio="0.6671802773497689" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495653978.jpeg" data-w="649" /></section> </section> </section> </section> <section style="text-align: left; box-sizing: border-box; transform: translate3d(5px, 0px, 0px);"> <section style="text-align: right; padding: 0px 20px; box-sizing: border-box;"> <p style="text-align: justify; margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 12px; color: #1a3b91; box-sizing: border-box;">►&nbsp;<span style="color: #54504f; box-sizing: border-box;">SARS-CoV-2借助ACE2受体进入细胞。</span></span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="transform-origin: center center; margin-top: 3px; margin-bottom: 3px; box-sizing: border-box; transform: scale(1.2);"> <section style="text-align: center; margin: -28px 0px 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"></section> </section> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">由浸大中医药学院教学科研部助理教授王凯亮博士带领的研究团队，与香港大学微生物学系助理教授袁硕峰博士合作，进一步研究产生可溶性ACE2的生理调节机制与新冠病原的关系。</strong></span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">该团队发现，感染新型冠状病毒会导致更多MT1-MMP被激活。</strong></span>MT1-MMP是一种对许多生理过程十分重要的蛋白酶，会令可溶性ACE2从带有ACE2的细胞中释放出来。可溶性ACE2继而与新型冠状病毒的刺突蛋白结合，并将其运送至未受感染且只有少量ACE2表现的细胞。</p> </section> <section style="transform-origin: center center; margin-top: 6px; margin-bottom: 6px; box-sizing: border-box; transform: scale(1.25);"> <section style="text-align: center; margin: 10px 0px -29px; line-height: 0; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"></section> </section> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; margin-top: 10px; margin-bottom: 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 537px; box-sizing: border-box; height: 358px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495745494.jpeg" width="537" height="358" data-ratio="0.6666666666666666" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495745494.jpeg" data-w="1080" /></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; font-family: Optima-Regular, PingFangTC-light; font-size: 12px;">► </span><span style="font-family: Optima-Regular, PingFangTC-light; font-size: 12px; color: #54504f;">王凯亮博士在媒体会上介绍新冠病毒治疗标靶的最新发现。</span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="transform-origin: center center; margin-top: 3px; margin-bottom: 3px; box-sizing: border-box; transform: scale(1.2);"> <section style="text-align: center; margin: -28px 0px 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"></section> </section> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">值得注意的是，团队证明把人类可溶性ACE2，注入因为体内ACE2与新冠病毒刺突蛋白不能结合，故先天性不容易受新冠病毒感染的实验品种小鼠（C57BL/6小鼠），能够令它们的肺部受到感染。<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">研究结果揭示了病毒「劫持」宿主酶，以增强其传染性，及引发多器官感染的机制。</strong></span></p> </section> <section style="transform-origin: center center; margin-top: 6px; margin-bottom: 6px; box-sizing: border-box; transform: scale(1.25);"> <section style="text-align: center; margin: 10px 0px -29px; line-height: 0; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"></section> </section> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 0px; box-sizing: border-box;"> <section style="display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; max-width: 100%; height: auto; box-sizing: border-box;"> <section style="text-align: center; box-sizing: border-box;"> <section style="display: inline-block; width: 34px; height: 64px; vertical-align: top; overflow: hidden; background-color: #1a3b91; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> <section style="display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; max-width: 100%; height: auto; box-sizing: border-box;"> <section style="box-sizing: border-box; transform: translate3d(-23px, 0px, 0px);"> <section style="font-size: 19px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #ffffff; box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="font-size: 36px; box-sizing: border-box;"><span style="color: #f2f9ff; box-sizing: border-box;">0</span><span style="color: #1a3b91; box-sizing: border-box;">3</span></span></strong></span></p> </section> </section> </section> <section style="display: inline-block; vertical-align: middle; width: auto; min-width: 5%; max-width: 100%; flex: 0 0 auto; height: auto; align-self: center; box-sizing: border-box;"> <section style="text-align: center; box-sizing: border-box;"> <section style="display: inline-block; width: 16px; height: 31px; vertical-align: top; overflow: hidden; background-color: rgba(115, 115, 115, 0.34); box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> <section style="display: inline-block; vertical-align: top; width: 70%; flex: 0 0 auto; height: auto; box-sizing: border-box;"> <section style="box-sizing: border-box; transform: translate3d(20px, 0px, 0px);"> <section style="text-align: justify; font-size: 20px; color: #54504f; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">抗体3A2抑制</strong></em></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">MT1-MMP活动&nbsp;</strong></em></p> </section> </section> </section> </section> <section style="margin: 0.5em 0px; box-sizing: border-box;"> <section style="background-color: rgba(54, 54, 54, 0.58); height: 2px; box-sizing: border-box;"></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 15px 0px 25px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 0) 70%, rgba(26, 59, 145, 0.96) 70%, rgba(26, 59, 145, 0.96) 100%); height: auto; padding: 0px 10px 10px; box-sizing: border-box;"> <section style="display: flex; width: 100%; flex-flow: column nowrap; box-sizing: border-box;"> <section style="z-index: 1; box-sizing: border-box;"> <section style="text-align: left; margin: 10px 0px -40px; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="display: inline-block; width: auto; height: 26px; vertical-align: top; overflow: hidden; background-color: rgba(214, 207, 205, 0.63); min-width: 5%; max-width: 100%; box-sizing: border-box; border: 0px none #ffffff;"> <section style="text-align: justify; color: rgba(214, 207, 205, 0.63); box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: rgba(0, 0, 0, 0.01); box-sizing: border-box;"> &nbsp;。</span></p> </section> </section> </section> </section> </section> <section style="margin: 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 100%; box-sizing: border-box; height: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495531893.jpeg" width="758" height="366" data-ratio="0.4830601092896175" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495531893.jpeg" data-w="915" /></section> </section> </section> </section> <section style="text-align: left; box-sizing: border-box; transform: translate3d(5px, 0px, 0px);"> <section style="text-align: right; padding: 0px 20px; box-sizing: border-box;"> <p style="text-align: justify; margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 12px; color: #1a3b91; box-sizing: border-box;">►&nbsp;<span style="color: #54504f; box-sizing: border-box;">COVID-19患者肺部组织中MT1-MMP的上调。</span></span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="transform-origin: center center; margin-top: 3px; margin-bottom: 3px; box-sizing: border-box; transform: scale(1.2);"> <section style="text-align: center; margin: -28px 0px 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"></section> </section> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">为研究MT1-MMP的作用，以及它如何影响病毒感染，研究人员使用人类细胞培育「类器官」，即一种在体外培植的三维组织结构，用作在实验室中模拟不同器官。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">他们发现，使用单克隆抗体3A2抑制MT1-MMP的活动，能有效减少可溶性ACE2的水平，<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">并将人类肺、心脏和肝脏类器官中新型冠状病毒的感染程度，降低60%至80%</strong></span>。使用新型冠状病毒的原始菌株，以及主要变种如Delta和Omicron进行实验，也得到相约结果。<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">研究结果显示，MT1-MMP是人体内调节新型冠状病毒进入细胞的主要因素，也是新冠药物的潜在治疗标靶。</strong></span></p> </section> <section style="transform-origin: center center; margin-top: 6px; margin-bottom: 6px; box-sizing: border-box; transform: scale(1.25);"> <section style="text-align: center; margin: 10px 0px -29px; line-height: 0; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"></section> </section> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="text-align: center; margin-top: 10px; margin-bottom: 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 466px; box-sizing: border-box; height: 310px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/168266349561148.jpeg" width="466" height="310" data-ratio="0.6657407407407407" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/168266349561148.jpeg" data-w="1080" /></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; font-family: Optima-Regular, PingFangTC-light; font-size: 12px;">►&nbsp;</span><span style="font-family: Optima-Regular, PingFangTC-light; font-size: 12px; color: #54504f;">COVID-19患者肺部组织中MT1-MMP的上调。</span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="transform-origin: center center; margin-top: 3px; margin-bottom: 3px; box-sizing: border-box; transform: scale(1.2);"> <section style="text-align: center; margin: -28px 0px 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"></section> </section> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">研究人员进一步测试把3A2应用于受新冠感染小鼠的效果。在11只小鼠之中，部份接受3A2治疗，部份则作为对照组。由于老龄是新冠重症和死亡的主要风险因素，故实验利用了老年小鼠进行。<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">结果显示，3A2把新型冠状病毒的数量减少近90%，并显著减轻由感染引起的肺组织破坏。</strong></span></p> </section> <section style="transform-origin: center center; margin-top: 6px; margin-bottom: 6px; box-sizing: border-box; transform: scale(1.25);"> <section style="text-align: center; margin: 10px 0px -29px; line-height: 0; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"></section> </section> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 0px; box-sizing: border-box;"> <section style="display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; max-width: 100%; height: auto; box-sizing: border-box;"> <section style="text-align: center; box-sizing: border-box;"> <section style="display: inline-block; width: 34px; height: 64px; vertical-align: top; overflow: hidden; background-color: #1a3b91; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> <section style="display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; max-width: 100%; height: auto; box-sizing: border-box;"> <section style="box-sizing: border-box; transform: translate3d(-23px, 0px, 0px);"> <section style="font-size: 19px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #ffffff; box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="font-size: 36px; box-sizing: border-box;"><span style="color: #f2f9ff; box-sizing: border-box;">0</span><span style="color: #1a3b91; box-sizing: border-box;">4</span></span></strong></span></p> </section> </section> </section> <section style="display: inline-block; vertical-align: middle; width: auto; min-width: 5%; max-width: 100%; flex: 0 0 auto; height: auto; align-self: center; box-sizing: border-box;"> <section style="text-align: center; box-sizing: border-box;"> <section style="display: inline-block; width: 16px; height: 31px; vertical-align: top; overflow: hidden; background-color: rgba(115, 115, 115, 0.34); box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> <section style="display: inline-block; vertical-align: top; width: 70%; flex: 0 0 auto; height: auto; box-sizing: border-box;"> <section style="box-sizing: border-box; transform: translate3d(20px, 0px, 0px);"> <section style="text-align: justify; font-size: 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #54504f; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">MT1-MMP</strong></em></span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #54504f; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">作为治疗标靶</strong></em></span></p> </section> </section> </section> </section> <section style="margin: 0.5em 0px; box-sizing: border-box;"> <section style="background-color: rgba(54, 54, 54, 0.58); height: 2px; box-sizing: border-box;"></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 15px 0px 25px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 0) 70%, rgba(26, 59, 145, 0.96) 70%, rgba(26, 59, 145, 0.96) 100%); height: auto; padding: 0px 10px 10px; box-sizing: border-box;"> <section style="display: flex; width: 100%; flex-flow: column nowrap; box-sizing: border-box;"> <section style="z-index: 1; box-sizing: border-box;"> <section style="text-align: left; margin: 10px 0px -40px; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="display: inline-block; width: auto; height: 26px; vertical-align: top; overflow: hidden; background-color: rgba(214, 207, 205, 0.63); min-width: 5%; max-width: 100%; box-sizing: border-box; border: 0px none #ffffff;"> <section style="text-align: justify; color: rgba(214, 207, 205, 0.63); box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: rgba(0, 0, 0, 0.01); box-sizing: border-box;"> &nbsp;。</span></p> </section> </section> </section> </section> </section> <section style="margin: 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 537px; box-sizing: border-box; height: 358px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495272246.jpeg" width="537" height="358" data-ratio="0.6657407407407407" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1682663495272246.jpeg" data-w="1080" /></section> </section> </section> </section> <section style="text-align: left; box-sizing: border-box; transform: translate3d(5px, 0px, 0px);"> <section style="text-align: right; padding: 0px 20px; box-sizing: border-box;"> <p style="text-align: justify; margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 12px; color: #1a3b91; box-sizing: border-box;">►&nbsp;<span style="color: #54504f; box-sizing: border-box;">3A2有很好的潜质开发成治疗新冠的有效药物。</span></span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="transform-origin: center center; margin-top: 3px; margin-bottom: 3px; box-sizing: border-box; transform: scale(1.2);"> <section style="text-align: center; margin: -28px 0px 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"></section> </section> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">王博士说：「如何提高对免疫系统较弱患者的疗效，以及维持药物在不同病毒株中的效用，是开发新冠药物的两大挑战。<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">3A2有很好的潜质开发成治疗新冠的有效药物，因为它旨在抑制MT1-MMP的活动，而并非增强患者的免疫力，或直接对付病毒。</strong></span>」</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">「我们之前发表的研究，证明3A2还可预防肥胖和糖尿病，即新冠重症和死亡的两个主要风险因素。因此，<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">3A2可能特别适合高危群组，包括老龄和有代谢功能障碍的病人</strong></span>。它亦可能对未来的新发性冠状病毒有效，因为对许多拥有类似细胞进入机制的病毒而言，ACE2都是它们的门户。把3A2应用于人类之前，需作进一步的研究和实验。」</p> </section> </section> </section> </section> </section> </section> <p style="display: none;">&nbsp;</p> </section>