<p>指南者留学全国统一咨询热线：<a href="tel:4001831832" style="color:#1677ff; text-decoration:none;">400-183-1832</a>，全国各地区、各分公司联系方式均为此号码。</p><section style="font-size: 16px;" data-role="outer"> <section style="margin-bottom: 0px; line-height: 1.75em; margin-left: 8px; margin-right: 8px;" data-mpa-powered-by="yiban.io"><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">最近这两天，一则新闻在香港的各个媒体上刷屏了&mdash;&mdash;</span></section> <section style="margin-bottom: 0px; line-height: 1.75em; margin-left: 8px; margin-right: 8px;"><span style="color: #b75941;"><strong><span style="color: #b75941; font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">理大与香港中文大学(中大)在合作研发新药物上取得重大突破，首创了一种可以治疗多种与肥胖症和胰岛素抵抗相关的代谢性疾病(如糖尿病和脂肪肝)的药物！</span></strong></span></section> <section style="text-align: center; margin-bottom: 8px; margin-left: 0px; margin-right: 0px;"><img class="rich_pages wxw-img js_insertlocalimg" style="max-width: 100%; height: 238px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907413703639.png" width="507" height="238" data-ratio="0.46944444444444444" data-s="300,640" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907413703639.png" data-type="png" data-w="1080" /></section> <section style="text-align: center; margin-left: 8px; margin-right: 8px; margin-bottom: 0px;"></section> <section data-mpa-template="t"> <section style="display: flex; justify-content: center; align-items: center; width: 100%; padding: 8px; box-sizing: border-box;" data-mid=""> <section style="display: flex; justify-content: flex-start; align-items: center; flex-direction: column; width: 100%;" data-mid=""> <section style="display: flex; align-items: center; width: 100%; justify-content: space-between;" data-mid=""> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 6px 0px 0px; margin-left: -3px; margin-bottom: -13px; box-sizing: border-box;" data-mid=""></section> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 6px 0px 0px; margin-right: -3px; margin-bottom: -13px; box-sizing: border-box;" data-mid=""></section> </section> <section style="background-color: #ffffff; border-radius: 5px; padding: 2px; width: 100%; z-index: 2; box-sizing: border-box; border: 1px solid #243a6d;" data-mid=""> <section style="width: 100%; border-radius: 5px; padding: 14px; box-sizing: border-box; border: 1px dashed #dbd9d9;" data-mid=""> <section style="font-size: 14px; font-family: PingFangSC-Regular, 'PingFang SC'; color: #243a6d; line-height: 1.75em;"><span style="font-size: 16px;">肥胖是全球普遍的健康问题。</span><span style="font-size: 16px;">根据世界卫生组织的统计，仅2016年，在全球成年人中，就有逾19亿人属于&ldquo;超重&rdquo;、6.5亿人属于&ldquo;肥胖&rdquo;，分别占成年人人口的39% 和13%。</span><span style="font-size: 16px;">而在香港，约两名成年人中，就有一人的体重指标被界定为&ldquo;超重&rdquo;或&ldquo;肥胖&rdquo;。</span></section> </section> </section> <section style="display: flex; align-items: center; width: 100%; justify-content: space-between;" data-mid=""> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 0px 0px 6px; margin-left: -3px; margin-top: -13px; box-sizing: border-box;" data-mid=""></section> </section> </section> </section> </section> <section style="line-height: 1.75em; margin: 32px 8px 0px;"><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">由<strong><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; color: #667595;">理大应用生物及化学科技学系教授、卢家骢慈善基金药物科学教授梁润松教授</span></strong>和<span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; color: #667595;"><strong>中大医学院生物医学学院副教授沈秀媛教授</strong></span>牵头研发的新药</span><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; color: #b75941;"><strong>ABarginase</strong></span><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">，是全球首款通过全新药理机制&ldquo;消耗精氨酸&rdquo;来治疗多种肥胖相关疾病的单一药物。ABarginase开辟了一条药效安全且持久的新路径&mdash;&mdash;在此之前，为</span><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">治疗上述这些相互关联的疾病，患者往往需要服用不同的药物，这会增加患者出现&ldquo;多药联用&rdquo;问题的风险。</span></section> <section style="line-height: 1.75em; margin-left: 8px; margin-right: 8px; margin-bottom: 0px;"></section> <section style="line-height: 1.75em; margin-left: 8px; margin-right: 8px; margin-bottom: 0px;"><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">ABarginase具有广阔的临床应用前景，它的<span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; color: #b75941;">适用症包括糖尿病前期、II 型糖尿病、非酒精性脂肪肝等</span><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; color: #b75941;">多种代谢疾病</span></span><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">，且</span><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; color: #b75941;">制药成本低、效率高</span><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">。因此，更多患者可以负担得起该药物并从中受惠。</span></section> <p>&nbsp;</p> </section> <p><img style="display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907413340771.png" width="516" height="271" data-ratio="0.525" data-s="300,640" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907413340771.png" data-type="jpeg" data-w="1000" /></p> <section style="font-size: 16px;" data-role="outer"> <p style="text-align: center; margin-left: 8px; margin-right: 8px; margin-bottom: 0px; line-height: 1.5em;"><span style="font-size: 14px; color: #888888;">研究团队主要成员：理大梁润松教授(左)、中大沈秀媛教授(右)。</span></p> <p style="margin-bottom: 0px; margin-left: 8px; margin-right: 8px; line-height: 1.75em;">&nbsp;</p> </section> <p><img style="display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907413337026.png" width="520" height="273" data-ratio="0.525" data-s="300,640" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907413337026.png" data-type="jpeg" data-w="1000" /></p> <section style="font-size: 16px;" data-role="outer"> <p style="text-align: center; margin-left: 8px; margin-right: 8px; margin-bottom: 0px; line-height: 1.5em;"><span style="font-size: 14px; color: #888888;">本次研究结合了理大在蛋白工程与药物开发方面的优势，以及中大在肥胖及糖尿病研究方面的领先实力。</span></p> <section data-mpa-template-id="453" data-mpa-category="模板"> <section data-mpa-category="模板" data-mid=""> <section data-mid=""> <section data-mid=""> <section data-mid=""> <section data-mid=""> <section data-mpa-template="t"> <section style="display: flex; justify-content: center; align-items: center; width: 100%; padding: 8px; box-sizing: border-box;" data-mid=""> <section style="display: flex; justify-content: flex-start; align-items: center; flex-direction: column; width: 100%; padding-left: 0px; padding-right: 0px; box-sizing: border-box;" data-mid=""> <section style="display: flex; align-items: center; width: 100%; justify-content: space-between;" data-mid=""> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 6px 0px 0px; margin-left: -3px; margin-bottom: -13px; box-sizing: border-box;" data-mid=""></section> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 6px 0px 0px; margin-right: -3px; margin-bottom: -13px; box-sizing: border-box;" data-mid=""></section> </section> <section style="background-color: #ffffff; border-radius: 5px; padding: 2px; width: 100%; z-index: 2; box-sizing: border-box; border: 1px solid #243a6d;" data-mid=""> <section style="width: 100%; border-radius: 5px; padding: 14px; box-sizing: border-box; border: 1px dashed #dbd9d9;" data-mid=""> <section style="font-size: 14px; font-family: PingFangSC-Regular, 'PingFang SC'; color: #243a6d; line-height: 1.75em;"><span style="font-size: 16px;">肥胖不仅会影响人们的体形，更会诱发糖尿病、非酒精性脂肪肝、心脏病、高血压、癌症等多种慢性病。</span></section> <section style="font-size: 14px; font-family: PingFangSC-Regular, 'PingFang SC'; color: #243a6d; line-height: 1.75em;"><br /><span style="font-size: 16px;">理大与中大的研究团队发现，当血液中一种半必需氨基酸&ldquo;精氨酸&rdquo;处于低水平时</span><span style="font-size: 14px;">(即&ldquo;精氨酸饥饿&rdquo;状态)</span><span style="font-size: 16px;">，细胞会抑制脂肪合成、促进脂肪分解并增强对胰岛素的敏感度。不过，一般情况下，人体内可分解精氨酸的&ldquo;精氨酸酶&rdquo;只有不足30分钟的循环半衰期，时间很短。</span></section> </section> </section> <section style="display: flex; align-items: center; width: 100%; justify-content: space-between;" data-mid=""> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 0px 0px 6px; margin-left: -3px; margin-top: -13px; box-sizing: border-box;" data-mid=""></section> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 0px 6px; margin-right: -3px; margin-top: -13px; box-sizing: border-box;" data-mid=""></section> </section> </section> </section> </section> </section> </section> </section> </section> </section> </section> <section style="line-height: 1.75em; margin: 0px 8px;"><span style="color: #667595;"><strong><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">梁润松教授</span></strong></span><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">介绍：&ldquo;通过采用先进的融合蛋白方法，我们的研究团队研制出一种长效的重组人类精氨酸酶ABarginase，它含有一个白蛋白结合域，能够与血液中稳定且充沛的白蛋白结合，从而可将循环半衰期延长约200倍。ABarginase具有较强的酶活性，每星期只需注射一个剂量，就足以使血液循环中的精氨酸保持在低水平，进而达到&lsquo;精氨酸饥饿&rsquo;的状态。&rdquo;</span></section> </section> <p><img style="display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907414699994.png" width="491" height="258" data-ratio="0.525" data-s="300,640" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907414699994.png" data-type="jpeg" data-w="1000" /></p> <section style="font-size: 16px;" data-role="outer"> <p>&nbsp;</p> <section style="margin-right: 8px; margin-bottom: 0px; margin-left: 8px; text-align: center; line-height: 1.5em;"><span style="font-size: 14px; color: #888888;">利用三D打印分子模型展示ABarginase、白蛋白与FcRn receptor在细胞表面的相互作用。</span></section> <section data-mpa-template="t"> <section style="display: flex; justify-content: center; align-items: center; width: 100%; padding: 8px; box-sizing: border-box;" data-mid=""> <section style="display: flex; justify-content: flex-start; align-items: center; flex-direction: column; width: 100%;" data-mid=""> <section style="display: flex; align-items: center; width: 100%; justify-content: space-between;" data-mid=""> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 6px 0px 0px; margin-left: -3px; margin-bottom: -13px; box-sizing: border-box;" data-mid=""></section> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 6px 0px 0px; margin-right: -3px; margin-bottom: -13px; box-sizing: border-box;" data-mid=""></section> </section> <section style="background-color: #ffffff; border-radius: 5px; padding: 2px; width: 100%; z-index: 2; box-sizing: border-box; border: 1px solid #243a6d;" data-mid=""> <section style="width: 100%; border-radius: 5px; padding: 14px; box-sizing: border-box; border: 1px dashed #dbd9d9;" data-mid=""> <section style="font-size: 14px; font-family: PingFangSC-Regular, 'PingFang SC'; color: #243a6d; line-height: 1.75em;"><span style="font-size: 16px;">研究人员为两组经饮食诱导的肥胖小鼠每周分别注射一次ABarginase和生理盐水。八周后，相比于注射生理盐水的对照组，ABarginase组的小鼠在体重、脂肪量、脂肪肝和糖尿病症状</span><span style="font-size: 14px;">(如高血糖、胰岛素抵抗、葡萄糖耐受不良)</span><span style="font-size: 16px;">等方面均恢复至正常水平。</span></section> </section> </section> <section style="display: flex; align-items: center; width: 100%; justify-content: space-between;" data-mid=""> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 0px 0px 6px; margin-left: -3px; margin-top: -13px; box-sizing: border-box;" data-mid=""></section> </section> </section> </section> </section> <p>&nbsp;</p> <p style="line-height: 1.75em; margin: 0px 8px;"><strong><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; color: #667595;">沈秀媛教授</span></strong><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">说：&ldquo;ABarginase在临床前研究阶段已经展现巨大潜力，有望为治疗多种与肥胖、胰岛素抵抗、糖尿病等相关的代谢性疾病提供安全有效的方案。其中，非酒精性脂肪肝至今没有获美国食物及药物管理局认可的药物，因此ABarginase的研发对于治疗非酒精性脂肪肝尤其意义重大。我们相信，可以治愈这些相关疾病的单一药物已经研发出来了。&rdquo;</span></p> <section data-mpa-template="t"> <section style="display: flex; justify-content: center; align-items: center; width: 100%; padding: 8px; box-sizing: border-box;" data-mid=""> <section style="display: flex; justify-content: flex-start; align-items: center; flex-direction: column; width: 100%;" data-mid=""> <section style="display: flex; align-items: center; width: 100%; justify-content: space-between;" data-mid=""> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 6px 0px 0px; margin-left: -3px; margin-bottom: -13px; box-sizing: border-box;" data-mid=""></section> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 6px 0px 0px; margin-right: -3px; margin-bottom: -13px; box-sizing: border-box;" data-mid=""></section> </section> <section style="background-color: #ffffff; border-radius: 5px; padding: 2px; width: 100%; z-index: 2; box-sizing: border-box; border: 1px solid #243a6d;" data-mid=""> <section style="width: 100%; border-radius: 5px; padding: 14px; box-sizing: border-box; border: 1px dashed #dbd9d9;" data-mid=""> <section style="font-size: 14px; font-family: PingFangSC-Regular, 'PingFang SC'; color: #243a6d; line-height: 1.75em;"><span style="font-size: 16px;">目前，研究团队已在多个国家为该新药申请了专利，并正提升制药工艺至符合生产质量管理规范(GMP)的品质要求，为开展临床试验做好准备。</span></section> </section> </section> <section style="display: flex; align-items: center; width: 100%; justify-content: space-between;" data-mid=""> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 0px 0px 6px; margin-left: -3px; margin-top: -13px; box-sizing: border-box;" data-mid=""></section> <section style="width: 16px; height: 16px; background-color: #ffc55b; border-radius: 0px 0px 6px; margin-right: -3px; margin-top: -13px; box-sizing: border-box;" data-mid=""></section> </section> </section> </section> </section> <section style="line-height: 1.75em; margin: 0px 8px;"><span style="font-size: 16px; font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif;">梁教授和沈教授表示：&ldquo;作为科学家，一直以来，我们都矢志为改善人类褔祉做出贡献。成功研发ABarginse可以说是为我们实现理想迈出的重要一步。&rdquo;</span></section> <p style="line-height: 1.75em; margin: 0px 8px; text-align: center;">&nbsp;</p> <p style="margin-left: 8px; margin-right: 8px; margin-bottom: 0px;"><span style="font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; font-size: 16px;">在第48届日内瓦国际发明展中，香港共有两项发明获得最高殊荣大奖，ABarginase就是其中之一，获颁&ldquo;发明者协会国际联合会最佳发明大奖&rdquo;</span><span style="font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; font-size: 16px;">。这既是对该款新药改善患者福祉、提升全球医疗卫生能力的肯定，也是对香港高校之间科研合作水平的国际级认可。</span></p> <p style="margin-left: 8px; margin-right: 8px; margin-bottom: 0px;">&nbsp;</p> <p style="margin-left: 8px; margin-right: 8px; margin-bottom: 0px;"><span style="font-family: 'Helvetica Neue', Helvetica, 'Hiragino Sans GB', 'Microsoft YaHei', Arial, sans-serif; font-size: 16px;">本研究得到卢家骢慈善基金有限公司、香港特区政府医务卫生局医疗卫生研究基金，以及理大化学生物学及药物研发国家重点实验室支持。</span></p> <p style="margin-left: 8px; margin-right: 8px; margin-bottom: 0px;">&nbsp;</p> </section> <p><img style="display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907414671190.png" width="438" height="230" data-ratio="0.525" data-s="300,640" data-src="https://editor-user.365editor.com/wechat/99/82/4969882/1684907414671190.png" data-type="jpeg" data-w="1000" /></p> <section style="font-size: 16px;" data-role="outer"> <p style="margin-right: 8px; margin-left: 8px; text-align: center; line-height: 1.5em; margin-bottom: 0px;"><span style="font-size: 14px; color: #888888;">卢家骢慈善基金有限公司董事卢伯韶先生(右四)、罗丽珊女士(右三)，研究团队主要成员梁润松教授(左三)、沈秀媛教授(左四)，理大应用生物及化学科技学系助理教授(研究)李文渊博士(左一)，中大研究及知识转移服务处处长徐仲鍈教授(右二)，理大知识转移及创业总监王家达先生(左二)，中大研究及知识转移服务处知识转移活动经理文志伟博士(右一)出席发布会。</span></p> <p style="display: none;">&nbsp;</p> </section>