<p>指南者留学全国统一咨询热线：<a href="tel:4001831832" style="color:#1677ff; text-decoration:none;">400-183-1832</a>，全国各地区、各分公司联系方式均为此号码。</p><section style="font-size: 16px;" data-role="outer"> <section style="font-size: 15px; line-height: 1.8; padding: 0px 10px; box-sizing: border-box; text-align: justify;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 5px 0px 10px; box-sizing: border-box;"> <section style="display: inline-block; vertical-align: top; width: auto; align-self: stretch; flex: 100 100 0%; height: auto; margin: 0px -10px; z-index: 0; padding: 15px; background-color: rgba(162, 191, 224, 0.16); box-sizing: border-box;"> <section style="text-align: justify; color: #3e3e3e; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">作为一种兼具经济效益，以及可实现实时监测胃肠道中辐射剂量、pH与温度值的可吞咽胶囊，可以使正在接受放射治疗的胃癌患者受益。</p> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; margin: 5px 0px 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 528px; box-sizing: border-box; height: 297px;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684144388573578.gif" width="528" height="297" data-ratio="0.562037037037037" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684144388573578.gif" data-w="1080" /></section> </section> <section style="font-size: 13px; color: #a0a0a0; line-height: 1.5; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="box-sizing: border-box;">▲</span>新加坡国立大学化学系刘小钢教授(左)和侯波博士是研发新型剂量计胶囊团队的主要成员。</p> </section> <section style="box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">胃癌是世界上最常见的癌症之一。</span></strong>来自新加坡国立大学的科研人员的一项新发明可以<span style="color: #3e3e3e; box-sizing: border-box;">通过提高放射治疗的精度，</span><strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">以实现高灵敏原位的辐射剂量检测，进而提高胃癌的治疗效果。</span></strong>在胃癌的治疗中，放射治疗通常与手术、化疗或免疫治疗等治疗方案结合使用。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">在现代放射治疗领域，精确靶向肿瘤组织，同时尽量减少对健康组织的损伤至关重要。然而，由于患者特异性、治疗不确定性以及递送方式的不同，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">低效以及不稳定的结果于放射治疗组织来说仍然是一项艰巨的挑战。</span></strong>实时监测辐射剂量（尤其是在胃肠道内）可以提高放射治疗的精度，进而提高治疗疗效，但这一点却很难实现。此外，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">用于监测pH值和温度变化等生化指标的现有方法也不足以对放射治疗进行全面的评估。</span></strong></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; border-style: solid; border-width: 4px 0px; border-color: #003d7c #456bb0; box-sizing: border-box;"> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(246, 246, 246, 0.99); padding: 15px; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">为了应对这一艰巨的挑战，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">新加坡国立大学理学院化学系刘小钢(Liu Xiaogang)教授领导的研究小组，</span></strong>与新加坡国立大学杨潞龄医学院、清华大学以及中国科学院深圳先进技术研究院的研究人员合作，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">研发出了一种可用于实时监测辐射剂量的可吞咽的X射线剂量计胶囊。</span></strong>结合新颖的胶囊设计以及基于神经网络的回归模型，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">该项工具能够根据捕获的信息计算辐射剂量。</span></strong>与此同时，研究小组还发现，该项工具能够提供比当前标准方法准确约5倍的剂量监测。</p> </section> </section> </section> </section> </section> <section style="box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">该项突破性的技术成果已于2023年4月13日在科学杂志《Nature Biomedical Engineering》上发表。</span></strong></p> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; justify-content: center; margin: 10px 0px 20px; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: auto; vertical-align: top; min-width: 10%; max-width: 100%; flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="justify-content: center; margin: 0px; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: auto; vertical-align: middle; min-width: 10%; max-width: 100%; flex: 0 0 auto; height: auto; background-color: #003d7c; padding: 7px; align-self: center; box-sizing: border-box;"> <section style="margin: 0px 0px -3px; box-sizing: border-box;"> <section style="color: #ffffff; text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;">当前技术的局限性</strong></p> </section> </section> </section> </section> </section> </section> <section style="box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">体内临床剂量计，如金属氧化物半导体场效应晶体管、X射线激发薄膜，通常直接放置在患者皮肤上，以估算目标区域吸收的剂量。虽然这种工具已被用于癌症的治疗与验证中，但同时，也面临着价格高昂、测量精度不足等问题。<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">因此，研发一种价格低廉的可吞咽传感器便尤为关键，</span></strong>以便在胃肠道放射治疗期间同时跟踪生化指标和X射线剂量。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: center; margin-top: 10px; margin-bottom: 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"><img style="vertical-align: middle; max-width: 100%; width: 508px; box-sizing: border-box; height: 286px;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684144388788302.gif" width="508" height="286" data-ratio="0.562962962962963" data-w="1080" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684144388788302.gif" /></section> </section> <section style="font-size: 13px; color: #a0a0a0; line-height: 1.5; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="box-sizing: border-box;">▲</span>胶囊尺寸为18毫米&nbsp;&times; 7毫米，是许多补充剂和药品的常见尺寸。</p> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; justify-content: center; margin: 10px 0px 20px; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="justify-content: center; margin: 0px; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: middle; flex: 0 0 auto; height: auto; background-color: #003d7c; align-self: center; padding: 7px 0px 7px 3px; box-sizing: border-box;"> <section style="margin: 0px 0px -3px; box-sizing: border-box;"> <section style="color: #ffffff; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;">一种可吞咽胶囊</strong></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;">可实时监测胃肠道中的辐射剂量、pH与温度值</strong></p> </section> </section> </section> </section> </section> </section> <section style="box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">为了克服目前癌症治疗中面临的局限性，刘小钢教授研发了一种可吞咽的X射线剂量计胶囊，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">能够在放射治疗期间实时监测胃肠道中的辐射剂量，以及pH值与温度的变化情况。</span></strong>该胶囊的核心部分包括一根柔性光纤，内嵌纳米闪烁体，在有辐射的情况下会发光；一层用以监测局部pH变化的薄膜；一个用于动态胃液采样，且具有多个入口的流体模块；两个用于剂量和pH值测量的传感器；一个用于处理光电信号，能够将监测数据传输至应用程序的微控制器电路板；一个按钮大小的氧化银电池。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: center; margin-top: 10px; margin-bottom: 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"><img style="vertical-align: middle; max-width: 100%; width: 566px; box-sizing: border-box; height: 138px;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684144388175880.gif" width="566" height="138" data-ratio="0.24351851851851852" data-w="1080" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684144388175880.gif" /></section> </section> <section style="font-size: 13px; color: #a0a0a0; line-height: 1.5; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="box-sizing: border-box;">▲</span>剂量计胶囊的组成部分。(图片来源：《Nature Biomedical Engineering》，2023)</p> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="margin: 20px 0% 10px; text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; box-sizing: border-box; transform: translate3d(7px, 0px, 0px);"> <section style="display: inline-block; width: 100%; vertical-align: top; background-color: #003d7c; flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="margin: -6px 0% 6px; justify-content: center; display: flex; flex-flow: row nowrap; box-sizing: border-box; transform: translate3d(-6px, 0px, 0px);"> <section style="display: inline-block; width: 100%; vertical-align: top; background-color: #ffffff; align-self: flex-start; flex: 0 0 auto; padding: 10px 15px; box-sizing: border-box; border: 1px solid #003d7c;"> <section style="text-align: justify; padding: 0px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">当胶囊被摄入并到达胃肠道时，放射发光的强度随X射线剂量线性变化，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">纳米闪烁体在X射线剂量增加时会表现出更强的发光性。</span></strong>胶囊内的一个传感器测量来自纳米闪烁体的光亮，以确定目标区域吸收的辐射剂量。</p> </section> </section> </section> </section> </section> <section style="box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">与此同时，流体模块可以收集胃液，再搭配上能够根据pH值改变颜色的薄膜进行pH值检测，这种颜色变化由胶囊内的第二个传感器所捕捉。此外，这两个传感器还能够检测温度变化，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">从而捕获并显现放射治疗的任何负面反应，如过敏症状。</span></strong></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">来自两个传感器的光电信号由微型控制器处理，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">该处理器通过蓝牙和天线技术，将信息发送到手机应用程序。</span></strong>手机应用程序使用基于神经网络的回归模型处理原始数据，以显示诸如放射治疗的剂量、以及放射治疗过程中pH值和温度变化等信息。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="margin: 10px 0% 0px; text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; padding: 10px 15px; box-sizing: border-box; border: 1.5px solid #003d7c;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">刘小钢教授表示：&ldquo;我们的新型胶囊取得了&lsquo;改变游戏规则&rsquo;般的突破，为患者提供了负担得起的有效监测途径。它拥有广泛的应用潜力，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">为患者获得正确的放射剂量提供保障。&rdquo;</span></strong></p> </section> </section> </section> <section style="box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">该剂量计胶囊长18毫米，宽7毫米，是许多补充剂和药品的常见尺寸，生产成本为50新元。目前，<strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">该胶囊被设计用于实施监测胃肠道放疗期间的辐射剂量，也可以用于监测不同恶性肿瘤的治疗，</span></strong>并进一步定制胶囊的大小。例如，更小的胶囊尺寸可以使其放置在直肠中进行前列腺癌近距离治疗；或放置在上鼻腔中，用于实时测量鼻咽部或脑部肿瘤的吸收剂量，从而最大限度地减少对周围结构的辐射损伤。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: center; justify-content: center; margin: 10px 0px 20px; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: auto; vertical-align: top; min-width: 10%; max-width: 100%; flex: 0 0 auto; height: auto; align-self: flex-start; box-sizing: border-box;"> <section style="justify-content: center; margin: 0px; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: auto; vertical-align: middle; min-width: 10%; max-width: 100%; flex: 0 0 auto; height: auto; background-color: #003d7c; padding: 7px; align-self: center; box-sizing: border-box;"> <section style="margin: 0px 0px -3px; box-sizing: border-box;"> <section style="color: #ffffff; text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;">展望未来</strong></p> </section> </section> </section> </section> </section> </section> <section style="box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="color: #003d7c; box-sizing: border-box;">研究团队正在助力这一创新疗法从实验室走向临床应用，进一步的研究包括：</span></strong>在摄取后准确识别胶囊的位置和形态；研发一个强大的定位系统，以将胶囊固定在预期的靶点位置；开展更为精确的校准工作，以确保可吞咽剂量计的安全和有效临床使用。</p> </section> </section> <p style="display: none;">&nbsp;</p> </section>