昆士兰大学：COVID疫苗贴片比针头更好地对抗变种

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COVID疫苗贴片比针头更好地对抗变种

指南者留学 2022-07-28 14:26:35 阅读量：1399

<p>指南者留学全国统一咨询热线：<a href="tel:4001831832" style="color:#1677ff; text-decoration:none;">400-183-1832</a>，全国各地区、各分公司联系方式均为此号码。</p><div data-page-id="doxcnOjeQeMkGHV8ft82bMxBdAg" data-docx-has-block-data="true"> <div class="image-uploaded gallery old-record-id-doxcneqkmgiIkugiYMhGTjEY8Mf" data-type="image" data-ace-gallery-json="{"items":[{"uuid":"c57b37c1-ec94-44d0-b594-c0813a39a7a2","height":257,"width":420,"currHeight":257,"currWidth":420,"natrualHeight":257,"natrualWidth":420,"pluginName":"imageUpload","scale":1,"src":"https%3A%2F%2Finternal-api-drive-stream.feishu.cn%2Fspace%2Fapi%2Fbox%2Fstream%2Fdownload%2Fall%2FboxcnDzdL45yh1hcFQcebdTWHAh%2F%3Fmount_node_token%3DdoxcneqkmgiIkugiYMhGTjEY8Mf%26mount_point%3Ddocx_image","file_token":"boxcnDzdL45yh1hcFQcebdTWHAh","image_type":"image/jpeg","size":14879,"comments":[]}]}"><span class="p"><img style="display: block; margin-left: auto; margin-right: auto;" src="https://o7m7mpmybq.feishu.cn/space/api/box/stream/download/asynccode/?code=MjNhZmI5OTEyZGI4OWZkYjA2MTE5MDc3Yjc5M2I4MDFfSGRTSzFIdzFTaEI1dkxTS01SRVFBMk1oNnM4dzdXeDlfVG9rZW46Ym94Y25EemRMNDV5aDFoY0ZRY2ViZFRXSEFoXzE2NTg5ODk1ODg6MTY1ODk5MzE4OF9WNA" width="420" height="257" data-single-block="true" data-snapshot="eyJ0eXBlIjoiaW1hZ2UiLCJjaGlsZHJlbiI6W10sImNvbW1lbnRzIjpbXSwiYXV0aG9yIjoiNzExMTEyMzgyNzY4OTU4NjY5MiIsImltYWdlIjp7InNyYyI6IiIsInRva2VuIjoiYm94Y25EemRMNDV5aDFoY0ZRY2ViZFRXSEFoIiwibWltZVR5cGUiOiJpbWFnZS9qcGVnIiwic2l6ZSI6MTQ4NzksIm5hbWUiOiJib3hjbkR6ZEw0NXloMWhjRlFjZWJkVFdIQWguanBnIiwic2NhbGUiOjEsIndpZHRoIjo0MjAsImhlaWdodCI6MjU3fSwicGFyZW50X2lkIjoiZG94Y25PamVRZU1rR0hWOGZ0ODJiTXhCZEFnIn0=" 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justify;"><span class="p">根据昆士兰大学对小鼠的一项研究，无针疫苗贴片可以比传统的针头疫苗更好地对抗COVID-19变体，如Omicron和Delta。</span></div> <div class="ace-line ace-line old-record-id-doxcnYgCmUsYa2QAwQ78TdOsUlb" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcn0MG2mqyAIyICKYek9CqBTg" style="text-align: justify;"><span class="p">该研究与布里斯班生物技术公司Vaxxas合作进行，使用Vaxxas高密度微阵列贴片（HD-MAP）技术测试了Hexapro SARS-CoV-2刺杀疫苗，结果发现该贴片在中和COVID-19变体方面要有效得多。</span></div> <div class="ace-line ace-line old-record-id-doxcny6wQWwauQyEUwZcsDwsz5t" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcn4Mgsgk808CisKypJjKqcrf" style="text-align: justify;"><span class="p">昆士兰大学的Christopher McMillan博士说，疫苗贴片似乎比目前通过注射提供的SAR-CoV-2疫苗更有效地抵消了新变种。</span></div> <div class="ace-line ace-line old-record-id-doxcnoAO8icEyKSSSo9z6xKgpEb" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcna4C88OQCQgaAALGQNOOIFh" style="text-align: justify;"><span class="p">“高密度微阵列贴片是一种疫苗递送平台，可将疫苗精确地输送到富含免疫细胞的皮肤层中，”McMillan博士说。</span></div> <div class="ace-line ace-line old-record-id-doxcnGaCMWCo284gqsF99dwonmg" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcnIoasgAMAWYKe0MMMtuFoYg" style="text-align: justify;"><span class="p">“我们发现，与通过针头施用的相同疫苗相比，通过贴片接种疫苗在对抗Omicron变体方面的效果大约高出11倍。</span></div> <div class="ace-line ace-line old-record-id-doxcnwGq4WoO4YqoGaOq2dH5xhe" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcnE6uiCcCgSMgMGA3FwMuXXd" style="text-align: justify;"><span class="p">他说，结果比Hexapro疫苗更进一步。</span></div> <div class="ace-line ace-line old-record-id-doxcnQYyAGQ6WYY0i0E0RBRXo7f" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcnyKeoyayKmUgs4MHpjPpl8e" style="text-align: justify;"><span class="p">“到目前为止，我们通过贴片测试的每种疫苗类型，包括亚基，DNA，灭活病毒和偶联物，与传统的针头疫苗接种方法相比，都能产生卓越的免疫反应，”他说。</span></div> <div class="ace-line ace-line old-record-id-doxcne806AWECyOscwPTl48VyVe" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcn2MwaOeceUcA6QXcCPgzzdh" style="text-align: justify;"><span class="p">昆士兰大学教授David Muller博士表示，由于COVID-19的新变种不断涌现，目前可用的疫苗可能不那么有效，这让研究人员处于十字路口。</span></div> <div class="ace-line ace-line old-record-id-doxcnq6KmeaKEI0IMqghESMXJbf" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcn8E84kCMI2wuecL2KlJ52Eg" style="text-align: justify;"><span class="p">“这种降低的有效性在Omicron变体中得到了突出，该变体在刺突蛋白中含有30多个突变，”Muller博士说。</span></div> <div class="ace-line ace-line old-record-id-doxcnEOcEkgyICkyweetOkMcwQc" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcn2Iaw0cAGsAQ2WKsA0Lyz9f" style="text-align: justify;"><span class="p">“大量的突变使病毒能够逃避当前疫苗产生的免疫反应。</span></div> <div class="ace-line ace-line old-record-id-doxcnW4AIUKYakY4acjI3E1yOH5" style="text-align: justify;"><span class="p"> </span></div> <div class="image-uploaded gallery old-record-id-doxcnsCOwMGMOKIsA0iL7R5vAZg" data-type="image" data-ace-gallery-json="{"items":[{"uuid":"4c12d471-eb7b-4bba-9948-e0f0e6151774","height":413,"width":620,"currHeight":413,"currWidth":620,"natrualHeight":413,"natrualWidth":620,"pluginName":"imageUpload","scale":1,"src":"https%3A%2F%2Finternal-api-drive-stream.feishu.cn%2Fspace%2Fapi%2Fbox%2Fstream%2Fdownload%2Fall%2Fboxcnd3x1pjRTrOu5U5F6ezyblf%2F%3Fmount_node_token%3DdoxcnsCOwMGMOKIsA0iL7R5vAZg%26mount_point%3Ddocx_image","file_token":"boxcnd3x1pjRTrOu5U5F6ezyblf","image_type":"image/jpeg","size":325425,"comments":[]}]}"><span class="p"><img style="display: block; margin-left: auto; margin-right: auto;" 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data-suite="eyJmaWxlVG9rZW4iOiJib3hjbmQzeDFwalJUck91NVU1RjZlenlibGYiLCJvYmpUeXBlIjoiZG9jeCIsIm9ialRva2VuIjoiZG94Y25zQ093TUdNT0tJc0EwaUw3UjV2QVpnIiwib3JpZ2luU3JjIjoiaHR0cHM6Ly9pbnRlcm5hbC1hcGktZHJpdmUtc3RyZWFtLmZlaXNodS5jbi9zcGFjZS9hcGkvYm94L3N0cmVhbS9kb3dubG9hZC9hbGwvYm94Y25kM3gxcGpSVHJPdTVVNUY2ZXp5YmxmLz9tb3VudF9ub2RlX3Rva2VuPWRveGNuc0NPd01HTU9LSXNBMGlMN1I1dkFaZyZtb3VudF9wb2ludD1kb2N4X2ltYWdlIn0=" data-src="https://internal-api-drive-stream.feishu.cn/space/api/box/stream/download/all/boxcnd3x1pjRTrOu5U5F6ezyblf/?mount_node_token=doxcnsCOwMGMOKIsA0iL7R5vAZg&mount_point=docx_image" data-width="620" data-height="413" /></span></div> <div class="ace-line ace-line old-record-id-doxcnOC8uOSWwMIOu46tBTIQPie" style="text-align: center;"><span class="h6"><em>Christopher McMillan博士和David Muller博士在实验室。</em></span></div> <div class="ace-line ace-line old-record-id-doxcnm6aekU2MYYmCGUn3BZNwYc" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcnqkWKO6kU2o62kXh7HwSQoc" style="text-align: justify;"><span class="p">“然而，贴片技术有可能在我们的武器库中提供一种新的 - 更有效的 - 武器，而此时新变种正在迅速变异。</span></div> <div class="ace-line ace-line old-record-id-doxcn0sYUAuaKwIWgohuqVD24Qf" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcnEgouck6YaUAYiMPneQ93Yc" style="text-align: justify;"><span class="p">“这些贴剂不仅对新出现的变异更有效，而且比针头疫苗更容易管理。</span></div> <div class="ace-line ace-line old-record-id-doxcnwQmUiyka4MkAGmCBrQVNQf" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcnyWG8k6QsAa6A2mA9BpQmRf" style="text-align: justify;"><span class="p">“但是，重要的是要强调，现有疫苗仍然是对抗这种病毒引起的严重疾病的有效方法，现在不是放松警惕的时候。</span></div> <div class="ace-line ace-line old-record-id-doxcnUA48OKqAMu8y2hfWvbYjJY" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcna0wOcokI4Aqmo5Rs1gZVbf" style="text-align: justify;"><span class="p">Vaxxas首席执行官David Hoey表示，这进一步证明了该技术平台在帮助各国更好地应对当前和未来大流行等全球突发卫生事件方面可能具有改变游戏规则的潜力。</span></div> <div class="ace-line ace-line old-record-id-doxcnKkwESEcOscMYiD1txaXQos" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcnesUOKuK80YmeSv6DeB3yBl" style="text-align: justify;"><span class="p">“我们正在继续扩大我们的制造能力，并加速产品开发，为大规模临床试验做准备，”他说。</span></div> <div class="ace-line ace-line old-record-id-doxcn2gia8SuQEEUO4yuCSL8Iif" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcnsUaO8UyKy4SOCizBuWl8sd" style="text-align: justify;"><span class="p">“这包括在布里斯班建造我们的第一个生产设施，以支持我们的HD-MAP候选疫苗向商业化过渡，包括Hexapro COVID-19贴片。</span></div> <div class="ace-line" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcn0mWOiWm6w0gYEZKUWnnufc" style="text-align: justify;"><span class="p">该研究已发表在<em>《疫苗》上</em>。</span></div> <div class="ace-line ace-line old-record-id-doxcnGmgyskMQGAuWyoBo2sgdhc" style="text-align: justify;"><span class="p"> </span></div> <div class="ace-line ace-line old-record-id-doxcnukyyKQmOKY0ckTaSLKtaYg" style="text-align: justify;"><span class="p">该研究由David Muller博士获得的Advance Queensland Industry Research Fellowship资助。</span></div> <div class="ace-line ace-line old-record-id-doxcngMEo4E48IIi6oslxCx5XPm" style="text-align: justify;"> </div> </div>

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