牛津:血清素改变了人们学习和应对负面信息的方式
指南者留学 2024-09-18 15:29:11 阅读量:1096
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vertical-align: baseline; outline-width: 0px;"><img style="display: block; margin-left: auto; margin-right: auto;" src="https://info.compassedu.hk/sucai/content/1728285741247/1728285741247.png" width="654" height="323" /></p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">牛津大学<a style="margin: 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-style: none; text-decoration-line: none; color: #2f72a8;" href="https://www.psych.ox.ac.uk/">精神病学系</a>和国家健康与护理研究所 (NIHR)&nbsp;<a style="margin: 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-style: none; text-decoration-line: none; color: #2f72a8;" href="https://oxfordhealthbrc.nihr.ac.uk/">牛津健康生物医学研究中心 (OH BRC)</a>&nbsp;的科学家们的研究发现,血清素水平升高的人对惩罚性结果(例如,在游戏中输钱)的敏感性降低,而不会显着影响对奖励结果(赢钱)的敏感性。</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br />他们发现,增加血清素使个人能够更好地控制自己的行为,尤其是在接触负面信息时。该研究还表明,血清素水平升高有益于不同类型的记忆。</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br /><br />该论文的主要作者、牛津大学精神病学系的<a style="margin: 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-style: none; text-decoration-line: none; color: #2f72a8;" href="https://www.psych.ox.ac.uk/team/michael-colwell">迈克尔&middot;科尔威尔(Michael Colwell</a>)说:&ldquo;这些发现为血清素如何影响人类行为提供了新的视角,尤其是在负面环境中。</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br />&ldquo;我们相信它可能会为抑郁症的病因和治疗提供重要的见解。&rdquo;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br /><br />研究人员没有使用传统的抗抑郁药(SSRI 或选择性血清素再摄取抑制剂)来测试反应,而是使用一种新技术来测试血清素的作用,使用选择性血清素释放剂,这种药物目前用于治疗一种罕见的癫痫形式称为 Dravet 综合征。与传统技术不同,这种新药直接增加人脑中的血清素水平。</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br />牛津大学认知神经科学教授、OH BRC 抑郁症治疗学主题负责人&nbsp;<a style="margin: 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-style: none; text-decoration-line: none; color: #2f72a8;" href="https://www.psych.ox.ac.uk/team/catherine-harmer">Catherine Harmer 教授</a>说:&ldquo;尽管进行了近一个世纪的研究,但我们对血清素如何影响人类行为的理解仍然不清楚且存在争议。</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br /><br />&ldquo;这为我们提供了一些关于血清素在人类中的作用的令人兴奋的新信息。它表明,与抑郁症和抗抑郁药的作用有关的血清素在处理消极事物方面的作用更大,而不是促进积极反应。血清素通常被俗称为 &ldquo;快乐的化学物质&rdquo;,但也许现在是我们将其视为 &ldquo;不那么糟糕的化学物质 &rdquo;的时候了。</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br />牛津大学副教授&nbsp;<a style="margin: 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-style: none; text-decoration-line: none; color: #2f72a8;" href="https://www.psych.ox.ac.uk/team/susannah-murphy">Susannah Murphy 教授</a>说:&ldquo;通过直接操纵大脑中血清素的水平,这项研究帮助我们了解这种重要的大脑化学物质在人类中发挥的一些核心功能。</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br />&ldquo;我们的研究结果强调了血清素在努力的认知过程中发挥的核心作用,例如我们阻止不受欢迎的行为的能力。这项研究有助于进一步理解为什么改变血清素水平的药物是治疗许多精神疾病的有效方法,包括抑郁症、焦虑症和强迫症。</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br /><br />该研究涉及 26 名参与者,他们接受了增加血清素的药物,另有 27 名参与者在对照组中,他们被要求完成一系列测量学习和行为控制的任务。然后使用最先进的模型来了解参与者的行为。</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;">&nbsp;</p> <p style="margin: 0px 126.757px 1em 0px; padding: 0px; border-width: 0px; font-style: inherit; font-weight: inherit; font-stretch: inherit; font-size: 18px; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; outline-width: 0px;"><br /><span style="font-family: 'Tahoma For Number', 'Chinese Quote', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei', 'Helvetica Neue', Helvetica, Arial, sans-serif; color: #000000; font-size: 14px;">论文&ldquo;</span><span style="font-family: 'Tahoma For Number', 'Chinese Quote', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei', 'Helvetica Neue', Helvetica, Arial, sans-serif; color: #000000; font-size: 14px; font-style: inherit; font-weight: inherit;">人类直接释放血清素塑造厌恶学习和抑制</span><span style="font-family: 'Tahoma For Number', 'Chinese Quote', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei', 'Helvetica Neue', Helvetica, Arial, sans-serif; color: #000000; font-size: 14px; font-style: inherit; font-weight: inherit;">&rdquo;发表在</span><span style="font-family: 'Tahoma For Number', 'Chinese Quote', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei', 'Helvetica Neue', Helvetica, Arial, sans-serif; color: #000000; font-size: 14px; font-style: inherit; font-weight: inherit;">《自然通讯》</span><span style="font-family: 'Tahoma For Number', 'Chinese Quote', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei', 'Helvetica Neue', Helvetica, Arial, sans-serif; color: #000000; font-size: 14px; font-style: inherit; font-weight: inherit;">上。</span></p> </div>
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