<p>指南者留学全国统一咨询热线：<a href="tel:4001831832" style="color:#1677ff; text-decoration:none;">400-183-1832</a>，全国各地区、各分公司联系方式均为此号码。</p><div data-page-id="doxcnzfrnYhhLgEevEzQvlTKdqb" data-docx-has-block-data="true"> <div class="ace-line ace-line old-record-id-doxcneqKSCkg0cKIsQRBpq1pFjd"><span class="p">根据一项新的研究，血液测试可以通过识别血细胞产生的变化来提前几年预测老年人群中患白血病的风险。</span></div> <div class="ace-line ace-line old-record-id-doxcnGSoGGQsi4ywS6MwjNZ6Efh"><span class="p">&nbsp;</span></div> <div class="image-uploaded gallery old-record-id-doxcnkyYGiyaQYWOoIRnpw6M4ce" style="text-align: justify;" data-type="image" data-ace-gallery-json="{&quot;items&quot;:[{&quot;uuid&quot;:&quot;219c4b49-c369-4783-9c9e-290b83e24c9c&quot;,&quot;height&quot;:480,&quot;width&quot;:720,&quot;currHeight&quot;:480,&quot;currWidth&quot;:720,&quot;natrualHeight&quot;:480,&quot;natrualWidth&quot;:720,&quot;pluginName&quot;:&quot;imageUpload&quot;,&quot;scale&quot;:1,&quot;src&quot;:&quot;https%3A%2F%2Finternal-api-drive-stream.feishu.cn%2Fspace%2Fapi%2Fbox%2Fstream%2Fdownload%2Fall%2FboxcnK0Wxp9iXp2TGGm8CRdXB9b%2F%3Fmount_node_token%3DdoxcnkyYGiyaQYWOoIRnpw6M4ce%26mount_point%3Ddocx_image&quot;,&quot;file_token&quot;:&quot;boxcnK0Wxp9iXp2TGGm8CRdXB9b&quot;,&quot;image_type&quot;:&quot;image/jpeg&quot;,&quot;size&quot;:72553,&quot;comments&quot;:[]}]}"><span class="p"><img src="https://info.compassedu.hk/sucai/content/1658387324038/1658387324038.png" width="808" height="538" /></span></div> <div class="ace-line ace-line old-record-id-doxcnUosqMucuQISAEb7v565F9c"><span class="p">专家说，通过识别风险最大的人，应该有可能在未来提供预防性或早期治疗，以改善患者的预后。</span></div> <div class="ace-line ace-line old-record-id-doxcna4gQ6S44GmMayeSwpGGMsf"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcncIiyiAKsMy4qqYvPTw7mdd"><span class="p">白血病通常是血细胞生产中精细平衡中断的结果，其中制造新细胞而旧血细胞死亡。</span></div> <div class="ace-line ace-line old-record-id-doxcn4CeS6ywGMIOw437Pqwxd4g"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnWG2aw2K0wKUM6wwrNTMs9f"><span class="p">随着年龄的增长，血液干细胞的突变可能意味着改变的细胞可以比其他血细胞具有生长益处，并且在所谓的健身优势方面超过它们。</span></div> <div class="ace-line ace-line old-record-id-doxcnO4SAgGkmo0w6oPSSPPA8yb"><span class="p">&nbsp;</span></div> <h2 class="heading-2 ace-line old-record-id-doxcnGWs2aiioimC4aSvyYyx3Xb"><span class="p">调查更改</span></h2> <div class="ace-line ace-line old-record-id-doxcnAYqEEmuSSyMUqOC9vVfOGe"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnqsiAE86C8yC8G5wrWJ8H73"><span class="p">来自爱丁堡大学和格拉斯哥大学的研究人员调查了血液生产中发生的适应性优势的变化如何根据发生的突变类型为患白血病的风险提供线索。</span></div> <div class="ace-line ace-line old-record-id-doxcnEwUmioKkIgm4stQzpRakBc" style="text-align: justify;"><span class="p">&nbsp;</span></div> <blockquote class=" old-record-id-doxcnuEEeSQCqAOCUwP7jx52D6W" data-type="quote_container"> <div class="ace-line ace-line old-record-id-doxcnq2iKIOmU0aoYeONxOjJrue" style="text-align: justify;"><em><span class="h6">我们测量了洛锡安出生队列中83名老年人血液样本的变化，在12年内每三年采集一次。利用数学家，生物学家和基因组科学家的综合知识，我们开始了解这些变化对我们随着年龄增长而患白血病的风险意味着什么。</span></em></div> <div class="ace-line ace-line old-record-id-doxcnk4Mc2aayQcKcuYiG3tlkVd" style="text-align: justify;"><em><span class="h6">&nbsp;</span></em></div> <div class="ace-line ace-line old-record-id-doxcnU44gOYQkY8CCIDuvotq50f" style="text-align: justify;"><em><span class="h6">塔米尔&middot;钱德拉博士爱丁堡大学MRC人类遗传学系校长研究员</span></em></div> </blockquote> <div class="ace-line ace-line old-record-id-doxcn6EyoUOOIgWIeW2vj3uQ70e"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcniS6COYyqIuSqozZRmWR2dh"><span class="p">Lothian Birth Cohorts 1921和1936是对大脑，认知和一般衰老的纵向研究，每3年对1921年70至82岁的个体和1936年的79至92岁之间的个体进行随访。</span></div> <div class="ace-line ace-line old-record-id-doxcniEMs68wCgKUIxz0SkJ617J"><span class="p">&nbsp;</span></div> <h3 class="heading-3 ace-line old-record-id-doxcnIYiQQcoGiC2oUDNGjIJwzh"><span class="p">突变</span></h3> <div class="ace-line ace-line old-record-id-doxcn4qc8wU0SW2QIu1GpOMBxcb"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcni6GsYqoakmgmOYPhB3XWfh"><span class="p">然后，该团队将这些复杂的基因组数据与机器学习算法相结合，将不同的突变与携带这些突变的血液干细胞的不同生长速度联系起来。</span></div> <div class="ace-line ace-line old-record-id-doxcnWgYsW6QGU0gUmE6qAftlrf"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcncMosqWsCmGI82bxWHcNwnh"><span class="p">研究发现，特定的突变为在没有白血病的人中测量的干细胞提供了明显的适应性优势 - 这可以用来预测突变细胞生长的速度，这决定了白血病的风险。</span></div> <div class="ace-line ace-line old-record-id-doxcn420yA8sESWOY0u1KwXB3Xf"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnY6OKymckc4cMgNSrxRls8f"><span class="p">该团队表示，由于当前研究中的样本量有限，需要进一步的研究来验证这些结果在更大的人群中。</span></div> <div class="ace-line ace-line old-record-id-doxcnSiw6IMemA4wgS4SFl87z2b"><span class="p">&nbsp;</span></div> <blockquote class=" old-record-id-doxcnKmSe8cU4QIKoaKuMTQOT1c" data-type="quote_container"> <div class="ace-line ace-line old-record-id-doxcniAGYge2GUKeSU7ATcoQ5Qb" style="text-align: justify;"><span class="h6">在了解个体患者患白血病的风险后，临床医生可以安排那些最有可能患上这种疾病的人的预约间隔更短，并提供早期治疗，这更有可能成功。</span></div> <div class="ace-line ace-line old-record-id-doxcnOGgecueEaUiQiyy00F5r5c" style="text-align: justify;"><span class="h6">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnIkg6yuAMSG6s0rwKoYJXhb" style="text-align: justify;"><span class="h6">克里斯蒂娜&middot;基尔希纳博士共同主要作者，格拉斯哥大学癌症科学研究所高级讲师</span></div> <div class="ace-line ace-line old-record-id-doxcnOSeK8sCqS2sA8gbpBIGxGc" style="text-align: justify;"><span class="h6">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnsuuaIUGU4OIGYBfMfFquQe" style="text-align: justify;"><span class="h6">为了了解白血病的风险，我们需要考虑参与血细胞生产的不同细胞之间的平衡，以及这种平衡如何随着年龄的增长而变化。通过将基因组数据与机器学习联系起来，我们已经能够根据血细胞产生的突变来预测它们的未来行为。</span></div> <div class="ace-line ace-line old-record-id-doxcnImcCuY4ScEiwmeG9BVEg8b" style="text-align: justify;"><span class="h6">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnu08CcuUMk4GCEpUXelEnWg" style="text-align: justify;"><span class="h6">莱纳斯&middot;舒马赫博士爱丁堡大学再生医学中心的共同主要作者和校长研究员</span></div> </blockquote> <div class="ace-line ace-line old-record-id-doxcnOEIc44O6g6qiiKPuiscZlc"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnIIaeEAwcSsaeq2XjCDgssg"><span class="p">这些发现已发表在《自然医学》杂志上。这项研究由医学研究委员会，英国白血病和英国癌症研究中心资助。</span></div> <div class="ace-line ace-line old-record-id-doxcnoYw28GYmgyYGMz5vAZpUgQ"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnQMsYoCgsUQAsOsFZwJJW5d"><span class="p">Lothian Birth队列获得生物技术和生物科学研究委员会，经济和社会研究委员会，Age UK，Wellcome，皇家学会，医学研究委员会和爱丁堡大学的资助。</span></div> </div>